GUANGHAN, CHINA / ACCESSWIRE / Nyamavhuvhu 20, 2021 / Musi wa27 Kubvumbi, Zhang Ge, Sachigaro weBhodi uye Mutungamiriri weSichuan Deebio Pharmaceutical Co., Ltd. Semina.Vakataura pamusangano uyu, "Mushure memakore makumi maviri nemanomwe ebudiriro, takagadzira kubva mumusangano mudiki kuita kambani yemishonga yeAPI.Nhasi, Deebio inotungamira pasi rose bio-enzyme kugadzirwa uye R&D nyanzvi kambani. "
Zhang Ge aive nechivimbo nezvaaive ataura.Dhata rinoratidza kuti Deebio ine zvikwaniriso uye hunyanzvi hwekugadzira anopfuura gumi marudzi eBio-enzyme API, pakati peiyo kallidinogenase inogara pamusika wepasi rose;migove yemusika yepancreatin, pepsin, trypsin-chymotrypsin uye zvimwe zvigadzirwa zvese zvinodarika 30%;mumusika wepasi rose, Deebio ndiye ega API mutengesi we elastase, yakajeka mhinduro pepsin uye pancreatin ine yakakwira lipase chiitiko muChina.Kubva 2005, Deebio akawana CN-GMP uye EU-GMP certification, zvigadzirwa zvayo zvichitengeswa kunyika makumi matatu pasi rose, kusanganisira Europe, America, Japan neSouth Korea kwemakore anopfuura makumi maviri.Ishamwari yenguva refu yeSanofi, Celltrion, Nichi-Iko, Livzon nemamwe makambani emishonga ane mukurumbira.
"Izvi zvakabudirira zvinonyanya kubatsirwa nekuvandudza tekinoroji, manejimendi akajairwa uye kugadzirwa kwegirinhi."Zhang Ge akati, "Nekuda kwekuedza kusingaperi kwaDeebio kwemhando yepamusoro, zvigadzirwa zvebio-enzyme API zvine mabhenefiti akadai sekuita kwepamusoro, kuchena kwepamusoro uye kugadzikana kwepamusoro uye nekudaro zvinozivikanwa zvakanyanya nevadyidzani."
Kuita Zvakanakisisa
Bio-enzymes mapuroteni ane catalytic mabasa, ayo akasiyana nemamwe mapuroteni mukuti ane nzvimbo inoshanda.Iyo API yebio-enzymes inowanikwa nekuparadzaniswa, kubviswa uye kucheneswa kubva kune zvipenyu.
"Bio-enzyme API iindasitiri ine mari hombe, purofiti yakaderera uye njodzi huru yehunyanzvi.Chiyero cheindasitiri idiki.Uye kune makambani mashoma ari kuita izvi. "Sekureva kwaZhang Ge, njodzi yepamusoro yehunyanzvi inokonzerwa nebasa rema enzymes kuita kuti kucheneswa kuome.Semuenzaniso, kana iyo nzira isingadzoreki zvakanaka, chigadzirwa chinogona kunge chisina basa, uye zvino kurasikirwa nemushonga wayo.
Bio-enzyme API chimwe chezvakagadzirwa zvebio-mishonga.Nehupfu hwakaderera uye mhedzisiro, bio-mishonga inonangwa zvakanyanya kurapwa kwezvimwe zvirwere uye inotorwa nyore nyore nemuviri wemunhu.Iyo ine yakasarudzika yekurapa mhedzisiro yechirwere cheshuga, chirwere chemoyo, mamota uye zvirwere zvehutachiona.
"Uzivi hwangu hunogara huripo ndehwekuti chero ndichiita zvisingaitwe nevamwe, ndinozviita zvakanyanya."Zhang Ge anotenda kuti chikonzero chekuti ave akadzika midzi muindasitiri yebio-enzyme kwemakore anopfuura makumi maviri kuda kwake maenzayimu nemoyo wese.Muna 1990, apedza kudzidza kubva kuSichuan University (Yaimbova Chengdu University of Science and Technology) zvikuru mubiochemistry, Zhang Ge akashanda senyanzvi uye akazova mutungamiriri werabhoritari muDeyang Biochemical Pharmaceutical Factory.Makore mashanu gare gare, nekuda kwekugadziridzwa kwefekitari, akatora bhizinesi.
“Panguva iyoyo, fekitari yemakemikari omuviri yakanga yava kuda kuchinjwa kuva kambani yemishonga.Ndakaenda kufekitari kunotarisa ndokuona kuti vanhu vaduku vashomanene vakanga vachigadziridza kashopu duku yekare.Zviso zvavo zvakanga zvazara nemvura nemadhaka.Pakati pavo paiva naZhang Ge. "Zhong Guangde, aimbova Mutevedzeri weMukuru weSichuan Provincial Medical Administration Bureau, anoyeuka nemanzwiro, "Zhang Ge achiri jaya riya riri kuita zvinhu zvinoshanda mumaziso angu."
Muna Zvita 1994, Zhang Ge akatanga Sichuan Deyang Biochemical Products Co., Ltd. Payakangotangwa, yakapotsa yaparara.
"Mukutanga kwema1990, ruzivo rwemhando yeindasitiri yeBio-enzyme yeChina kazhinji rwakanga rusina kusimba, uye manzwisisiro atinoita maenzayimu akange achiri mashoma pakuziva kuti kuita kwakanaka kwemaenzayimu kwakakwana."Sekureva kwaZhang Ge, muna Kurume 1995, iyo ichangoburwa Deyang Biochemical Products Co., Ltd. yakawana odha yayo yekutanga ye crude kallidinogenase kuti iendeswe kumusika weJapan.Zvisinei, zvigadzirwa zvakarambwa nekuda kwekusiyana kwemamirigiramu mashomanana mumafuta.“Kana rimwe divi rikakumbira muripo, kambani yaibva yashaya mari, uye mari yemuripo yaikwira kukambani panguva iyoyo.Neraki, kuburikidza nekubatana, rimwe bato harina kutikumbira kuti tibhadhare asi ngatipei zvakare zvigadzirwa, ”akadaro Zhang Ge.
Chiitiko ichi chakadzidzisa Zhang Ge, uyo akanga achangotanga bhizinesi, chidzidzo chakakosha uye chakaita kuti aone kuti kunaka kwechigadzirwa ndiro ropa rekambani.Mumakore makumi maviri nemanomwe anotevera ebudiriro, kambani yagara ichitevedzera kuomarara kwemhando zviyero.Kubva pamakore ekutsvagisa kwekutanga, Deebio yakagara ichivandudza tekinoroji yayo, nekudaro ichigadzira yakazara-yekuita enzyme kuchengetedzwa kwekuita, kusingaparadze activation uye chaiyo yekuchenesa tekinoroji kuti ive nechokwadi chekuita kwepamusoro, kuchena kwepamusoro uye kugadzikana kwakanyanya kweBio-enzyme API zvigadzirwa.
Kuchengetedza Hapana Kuedza Kuisa Mari muInnovation
"Indasitiri yebio-enzyme API inoratidzwa nemari shoma uye kusiyanisa.Pasina hunyanzvi hwekuita tekinoroji, chigadzirwa chimwe kana zviviri hazvigone kutsigira kambani kugadzira.Deebio ine chigadzirwa chimwe chete kubva payakatangwa.Asi nhasi kune anopfuura gumi nemaviri bio-enzyme APIs, iyo isingaparadzaniswe kubva mukuenderera kwedu kwekudyara muhunyanzvi.Zhang Ge akadaro.
Trypsin-Chymotrypsin iproteolytic enzyme yakaparadzaniswa uye yakacheneswa kubva kune porcine pancreas.Icho chimwe chezvigadzirwa zvikuru zveDeebio.Iyo R&D yechigadzirwa ichi yakabatsirwa kubva kuindasitiri-yunivhesiti-tsvakurudzo yekudyidzana.Muna 1963, Qi Zhengwu, muongorori paShanghai Institute of Physiology and Biochemistry yeChinese Academy of Sciences, akashandisa recrystallization kubvisa kristaro yakasanganiswa yechymotrypsin uye trypsin kubva muporcine pancreas, iyo yakanzi trypsin-chymotrypsin.Iyi enzyme yakanga isati yagadzirwa kwemakore anopfuura makumi matatu.Zhang Ge akaona mukana mairi."Muna 1997, takabatana neboka rekutsvagisa renyanzvi Qi Zhengwu kuona maindasitiri etrypsin-chymotrypsin uye takawana zvakanaka zvehupfumi nemagariro.Panguva yayo yakanakisisa, anopfuura matani makumi maviri pagore echigadzirwa ichi akatumirwa kuIndia.”Sekureva kwaZhang Ge, nyanzvi yezvidzidzo Qi Zhengwu akati "Zvinoshamisa, zvigadzirwa zvangu zvakagadziridzwa nemabhizinesi emataundishipi uye emumusha.
Mushure mekuravira kutapira kwehunyanzvi hwekuvandudza tekinoroji, Deebio yakawedzera kuwedzera mari yayo mune tekinoroji, uye yakagadzira yepedyo indasitiri-yunivhesiti-tsvakurudzo yekudyidzana neTsinghua University, Chinese Academy of Sciences, Sichuan University, China Pharmaceutical University nemamwe masangano edzidzo yepamusoro uye masangano ekutsvagisa. , kuvaka pamwe chete marabhoritari, kuenderera mberi nekuvandudza tsvakiridzo yesaenzi nehunyanzvi hwekuvandudza uye kuvaka chikwata chekugadzira neR&D chine hunyanzvi hwekushandura tekinoroji iyo yakawana zvakatevedzana matekinoroji gumi neshanu ane patented.
Kuti tienderere mberi nekuvandudza kunaka kwechigadzirwa, muna 2003, Deebio akabatana nemumwe wekuGermany ane tekinoroji yepamusoro nehunyanzvi hwekutungamira kuti vatange mubatanidzwa unonzi Deyang Sinozyme Pharmaceutical Co., Ltd. “Mugore iroro, takaisa mari inodarika mamiriyoni makumi maviri kuvaka chirimwa chitsva, chine michina yekugadzira iri kuvakwa nezvinhu zvepamusoro-soro pasi rose.Munguva imwecheteyo, fekitori inogona kuvakwa muChina kwemamiriyoni mashanu emayuan.Mutengo wekuvaka Sinozyme wakaenzana neyemafekitori mana. "Sekureva kwaZhang Ge, mubatsiri weGerman akashanyira kambani iyi kuti ape gwara kwemazuva gumi mwedzi wega wega.Nekuunzwa kwemhando yepamusoro hurongwa hwekutarisira nzira, Sinozyme's quality system management kugona kwakasimudzwa kusvika padanho repamusoro repasirese.
Muna 2005, Sinozyme yakava yekutanga Chinese pancreatin kambani kuwana EU-GMP certification;muna 2011, Sichuan Deebio Pharmaceutical Co., Ltd. yakatangwa;mu2012, Deebio akawana CN-GMP certification;muna Ndira 2021, Deebio (Chengdu) Bio-technology Co, Ltd.
“Ini ndinofunga makambani anofanirwa kuda kuisa mari mukugadzira tekinoroji.Deebio akavaka fekitari nyowani makore manomwe kusvika masere ega ega.Mumakore aya, mapurofiti mazhinji akaiswa mukuvaka bhizinesi, shanduko yemidziyo yekugadzira uye kusuma tarenda.Vagovani nemamaneja vanowana migove mishoma. ”Zhang Ge, aimbove mainjiniya, anonzwisisa zvizere kukosha kwekudyara tekinoroji.Akachengetedza kukurumidza kwekuvandudza, uye akaronga zvinhu zvakatevedzana: Deebio's new GMP workshop yakavakwa maererano nemitemo yeFDA yakatangwa gore rapera uye inotarisirwa kupedzwa mukupera kwaMay uye kupinda mukugadzirwa kwekuedza;Deebio (Chengdu) Bio-technology Co., Ltd., iri muWenjiang, Chengdu, yakatanga kuvaka zviri pamutemo muna Kubvumbi 26 uye inotarisirwa kuiswa zviri pamutemo muna Gumiguru.
"Green Production Ndiko Kunyanya Kudada Nayo"
Kusvibiswa kwe API kwagara kuri kunetseka munharaunda, uye kuchengetedzwa kwezvakatipoteredza kwave kukwirisa-tension point inotaridza kupona kwemabhizinesi.Kuomerera kune kugadzirwa kwegirinhi ndizvo zvinonyanya kudada nazvo Zhang Ge.
“Pakutanga kuvandudzwa kwekambani iyi, hatina kunyanya kukoshesa nyaya dzezvakatipoteredza.Asi zvadaro, nyika payaiisa pamberi pekuchengetedzwa kwezvakatipoteredza, takatanga kuona kukosha kwayo. "Sekureva kwaZhang Ge, mumakore gumi apfuura, Deebio akateerera zvakanyanya kwazviri, achiedza kuwana budiriro inoenderera.
Chakanga chiri chiitiko chakakurudzira kuchinja.“Pamusangano wakaitwa makore mazhinji apfuura, vakuru vekambani yedu vaironga nezvechigadzirwa chaida mamwe machemical reagents.Imwe yemakemikari reagents haigone kuderedzwa uye, kana mvura yakasvibiswa ikaiswa murwizi, inogona kukonzera kuremara kwevana.Ndakanga ndisina kuzeza kuramba chigadzirwa ichi. "Achitaura nezve chiitiko ichi, Zhang Ge akashungurudzika zvikuru, "Guta rangu rekumusha riri padivi peRwizi rweTuojiang, rwuri makiromita anopfuura mazana maviri kubva kuGuanghan, Sichuan.Uye rwizi ruri pedyo nefekitari yedu runoyerera ruchipinda muRwizi rwaTuojiang.Kurasa tsvina yakananga imhosva kuzvizvarwa zvinotevera.Saka ini handiite zvakadaro.
Kubva ipapo, Deebio akataura kuti chero kugadzirwa kunosanganisira muchetura uye nengozi zvinhu zvemakemikari zvakabikwa kana zvinhu zvekubatsira izvo zvisingakwanisi kugadziriswa mukugadzirwa kwezvigadzirwa zvitsva, kusimudzira hakuzotenderwe, uye yakasimbirira kuisa mari mukuchengetedza kwezvakatipoteredza. anopfuura makore gumi.
Nhasi, Deebio akavaka nzvimbo yekuchenesa mvura yegadheni ine 1,000m³ yekurapisa zuva nezuva, iine tsvina iri kubuda mushure mekusvika pachiyero.“Kugona uku kunokwana kuti tishandise kwemakore gumi.Uye gadheni rakavakwa zvakanyanya pamusoro penzvimbo yekuchenesa mvura yemarara.Mvura yakacheneswa inogona kushandiswa kusimudza hove nekunwisa maruva,” Zhang Ge akadaro achizvikudza.
Pamusoro pezvo, gasi remarara rinogona kurapwa nekupfapfaidza uye nedzimwe nzira, uye iyo biogas inogona kushandiswa kupisa bhailer mushure mekubvisa uye kupera simba, nekudaro kuchengetedza 800m³ yegasi rechisikigo zuva rega rega.Kune dzakaoma dzakagadzirwa, kune yakakosha yakasimba yekugadzirisa musangano.Tsvina yemapuroteni inoshandurwa kuita fetiraiza yebhayoloji mukati memaminetsi mana kuburikidza nemuomesa uye inotumirwa kune biological fetireza chirimwa.
Zhang Ge akati nechemumoyo, "Ikozvino nzvimbo yese yechirimwa haiburitse chero munhuwi wakasiyana, uye mvura yakaraswa uye zvinosvibisa zvinodzorwa nenzira yakarongeka.Ndinodada nazvo kupfuura kugadzirwa kwezvinhu, inova budiriro yandinokoshesa zvikuru.”
Nezve budiriro yeramangwana, Zhang Ge azere nechivimbo, “Kusimukira kweindasitiri kunoda kufambira mberi.Iko kusimudzira kwemhando yepamusoro kweiyo bio-enzyme API indasitiri hairevi chete kugadzirwa kwemhando yepamusoro, asi zvakare kuve nehunyanzvi hwepamusoro, mashandiro anoshanda, hutungamiriri hwepamusoro zvinodiwa, uye nzira dzekugadzira dzine hushamwari.Deebio achatora hutungamiriri hwebudiriro yemhando yepamusoro yeindasitiri sebasa rayo, uye nemoyo wese kushandira vanhu vese nekuda kwehutano hwavo munzira yekuvandudza. "
Nguva yekutumira: Aug-20-2021
